Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | activates | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
A303R | site-directed mutagenesis, the mutation interferes with calcium/calmodulin binding and activation of CAMK2B, as well as the autonomous (calcium/calmodulin-independent) activity of CAMK2B, and renders CAMK2B into a persistently F-actin bound state | Mus musculus |
additional information | generation of a Camk2b knockout mutants by deletion of exon 11 | Mus musculus |
T287A | site-directed mutagenesis, an autophosphorylation-deficient CAMK2B mouse mutant. Nearly complete absence of T287-phosphorylated CAMK2B in Camk2bT287A/T287A mice without changes in T286-phosphorylated CAMK2A or total levels of both CAMK2A and CAMK2B | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
synapse | - |
Mus musculus | 45202 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required, activates | Mus musculus | |
Mg2+ | required | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P28652 | - |
- |
Mus musculus C57BL/6 | P28652 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain cortex | - |
Mus musculus | - |
cerebellum | cerebellar granule cells | Mus musculus | - |
forebrain | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
neuron | glutamatergic pyramidal neurons in hippocampus and cortex | Mus musculus | - |
Purkinje cell | - |
Mus musculus | - |
striatum | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent protein kinase type 2 | - |
Mus musculus |
CAMK2B | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Camk2b-/- mice, which lack the beta isoform of calcium/calmodulin-dependent protein kinase 2 (CAMK2B), show very severe locomotion deficits, while global deletion of Camk2b in the adult mouse causes only mild locomotion deficits, suggesting that the severe locomotion deficits of Camk2b-/- mice are largely of developmental origin. Early onset deletion of Camk2b in cerebellum, striatum or forebrain do not recapitulate the locomotion deficits, suggesting that these deficits cannot be attributed to a single brain area. Most hippocampal phenotypes observed in Camk2b-/- mutants require CAMK2B protein, but not its enzymatic function | Mus musculus |
physiological function | CAMKII can have both structural and enzymatic functions in the brain. CAMK2B plays an important role in controlling the direction of synaptic plasticity at the parallel fiber. Normal locomotion requires calcium/calmodulin mediated activation of isozyme CAMK2B, but CAMK2B autonomous activity is largely dispensable. Molecular, temporal and region-specific role of CAMK2B in locomotion | Mus musculus |