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Literature summary for 2.7.11.17 extracted from

  • Kool, M.; Van De Bree, J.; Bodde, H.; Elgersma, Y.; Van Woerden, G.
    The molecular, temporal and region-specific requirements of the beta isoform of calcium/calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion (2016), Sci. Rep., 6, 26989.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin activates Mus musculus

Protein Variants

Protein Variants Comment Organism
A303R site-directed mutagenesis, the mutation interferes with calcium/calmodulin binding and activation of CAMK2B, as well as the autonomous (calcium/calmodulin-independent) activity of CAMK2B, and renders CAMK2B into a persistently F-actin bound state Mus musculus
additional information generation of a Camk2b knockout mutants by deletion of exon 11 Mus musculus
T287A site-directed mutagenesis, an autophosphorylation-deficient CAMK2B mouse mutant. Nearly complete absence of T287-phosphorylated CAMK2B in Camk2bT287A/T287A mice without changes in T286-phosphorylated CAMK2A or total levels of both CAMK2A and CAMK2B Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
synapse
-
Mus musculus 45202
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required, activates Mus musculus
Mg2+ required Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P28652
-
-
Mus musculus C57BL/6 P28652
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain cortex
-
Mus musculus
-
cerebellum cerebellar granule cells Mus musculus
-
forebrain
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Mus musculus
-
hippocampus
-
Mus musculus
-
neuron glutamatergic pyramidal neurons in hippocampus and cortex Mus musculus
-
Purkinje cell
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Mus musculus
-
striatum
-
Mus musculus
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Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent protein kinase type 2
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Mus musculus
CAMK2B
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

General Information

General Information Comment Organism
malfunction Camk2b-/- mice, which lack the beta isoform of calcium/calmodulin-dependent protein kinase 2 (CAMK2B), show very severe locomotion deficits, while global deletion of Camk2b in the adult mouse causes only mild locomotion deficits, suggesting that the severe locomotion deficits of Camk2b-/- mice are largely of developmental origin. Early onset deletion of Camk2b in cerebellum, striatum or forebrain do not recapitulate the locomotion deficits, suggesting that these deficits cannot be attributed to a single brain area. Most hippocampal phenotypes observed in Camk2b-/- mutants require CAMK2B protein, but not its enzymatic function Mus musculus
physiological function CAMKII can have both structural and enzymatic functions in the brain. CAMK2B plays an important role in controlling the direction of synaptic plasticity at the parallel fiber. Normal locomotion requires calcium/calmodulin mediated activation of isozyme CAMK2B, but CAMK2B autonomous activity is largely dispensable. Molecular, temporal and region-specific role of CAMK2B in locomotion Mus musculus