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Literature summary for 2.7.11.17 extracted from

  • Bele, T.; Fabbretti, E.
    The scaffold protein calcium/calmodulin-dependent serine protein kinase controls ATP release in sensory ganglia upon P2X3 receptor activation and is part of an ATP keeper complex (2016), J. Neurochem., 138, 587-597.
    View publication on PubMed
Search for more literature for 2.7.11.17

Inhibitors

Inhibitors Comment Organism Structure
KN-93
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Mus musculus
Mg2+ required Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ganglion trigeminal ganglia Mus musculus
-
neuron sensory Mus musculus
-

Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent serine protein kinase
-
 Mus musculus
CaMKII
-
 Mus musculus
CASK
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the scaffold protein calcium/calmodulin-dependent serine protein kinase negatively controls ATP release in sensory ganglia upon P2X3 receptor activation and is part of an ATP keeper complex. The ability of P2X3 receptors to transduce extracellular stimuli into neuronal signals critically depends on the dynamic molecular partnership with thecalcium/calmodulin-dependent serine protein kinase, CASK has a negative role in P2X3-mediated ATP release. CASK-controlled ATP efflux follows P2X3 receptor activity, but not depolarization-evoked ATP release. CASK is essential for the transactivation of Panx1 upon P2X3 receptor activation Mus musculus