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Literature summary for 2.7.11.17 extracted from

  • Nafzger, S.; Rougier, J.S.
    Calcium/calmodulin-dependent serine protein kinase CASK modulates the L-type calcium current (2016), Cell Calcium, 61, 10-21.
    View publication on PubMed
Search for more literature for 2.7.11.17

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression in TsA-201 cells, the recombinant enzyme interacts and co-localizes with the presynaptic N-type voltage-dependent calcium channel (Cav2.2) and induces in TsA-201 cell line an increase of calcium current mediated by this channel Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNa silencing of CASK after its transfection in TsA-201 cells. The CASK silencing does not modulate Cav1.2 subunits expression, the effect mediated by CASK silencing is a dynamic process. Silencing of CASK increase the open probability of the calcium channel via activation of calcineurin through cleavage by a phosphatase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information in cardiomyocytes, the enzyme CASK is present at the lateral membrane and also in a striated pattern, suggesting the presence of this kinase close to or within the T-tubule system Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Homo sapiens
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cardiomyocyte
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 Homo sapiens
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heart
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 Homo sapiens
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neuron
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent serine protein kinase
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 Homo sapiens
CASK
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 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
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 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction after CASK silencing, single calcium channel recordings show an increase of the voltage-gated calcium channel Cav1.2 open probability explaining the increase of the whole-cell current Homo sapiens
physiological function molecular mechanisms of protein kinase regulation by calcium/calmodulin, overview. CASK negatively regulates the cardiac Cav1.2 calcium current expressed in mammalian cell lines via the modulation of the open channel probability. The enzyme interacts and co-localizes with the presynaptic N-type voltage-dependent calcium channel (Cav2.2) in mature hippocampal neurons. CASK has a major role in neurological disorder called X-linked mental retardation Homo sapiens