Literature summary for 2.7.11.17 extracted from

Salzano, M.; Rusciano, M.R.; Russo, E.; Bifulco, M.; Postiglione, L.; Vitale, M.
Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation (2012), Cell Cycle, 11, 2100-2106.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Ras(V12)	activates the enzyme, which, in turn, phosphorylates Raf-1 at Ser338 and participates in extracellular signal-regulated kinase activation upon different stimuli	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	CaMKII1-290 is a truncated sequence of CaMKII that makes the enzyme constitutively active	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + Raf-1 protein	Rattus norvegicus	the enzyme phosphorylates Raf-1 at Ser338 and mediates Ras-stimulated Raf-1 activation	ADP + phosphorylated Raf-1 protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + Raf-1 protein	-	Rattus norvegicus	ADP + phosphorylated Raf-1 protein	-	?
ATP + Raf-1 protein	the enzyme phosphorylates Raf-1 at Ser338 and mediates Ras-stimulated Raf-1 activation	Rattus norvegicus	ADP + phosphorylated Raf-1 protein	-	?

Synonyms

Synonyms	Comment	Organism
calcium/calmodulin-dependent protein kinase II	-	Rattus norvegicus
CaMKII	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	the enzyme phosphorylates Raf-1 at Ser338 and mediates Ras-stimulated Raf-1 activation	Rattus norvegicus

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Release 2023.1 (January 2023)