Literature summary for 2.7.11.17 extracted from

Choi, Y.H.; Ann, E.J.; Yoon, J.H.; Mo, J.S.; Kim, M.Y.; Park, H.S.
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability (2013), Biochim. Biophys. Acta, 1833, 69-79.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + Notch1 protein	Mus musculus	phosphorylation of Notch1 intracellular domain inhibits the proteasomal degradation of Notch1 intracellular domain through Fbw7 ubiquitin-protein ligase complex. Upregulated Notch1 intracellular domain accelerates osteoclast differentiation	ADP + phosphorylated Notch1 protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P08414	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + Notch1 protein	-	Mus musculus	ADP + phosphorylated Notch1 protein	-	?
ATP + Notch1 protein	phosphorylation of Notch1 intracellular domain inhibits the proteasomal degradation of Notch1 intracellular domain through Fbw7 ubiquitin-protein ligase complex. Upregulated Notch1 intracellular domain accelerates osteoclast differentiation	Mus musculus	ADP + phosphorylated Notch1 protein	-	?

Synonyms

Synonyms	Comment	Organism
calcium/calmodulin-dependent protein kinase IV	-	Mus musculus
CaMKIV	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	calcium/calmodulin-dependent protein kinase IV enhances osteoclast differentiation via the up-regulation of Notch1 protein stability	Mus musculus

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Release 2023.1 (January 2023)