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Literature summary for 2.7.11.17 extracted from

  • Hoffman, L.; Farley, M.M.; Waxham, M.N.
    Calcium-calmodulin-dependent protein kinase II isoforms differentially impact the dynamics and structure of the actin cytoskeleton (2013), Biochemistry, 52, 1198-1207.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.17

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13555
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Homo sapiens Q13557
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-
Rattus norvegicus P08413
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Rattus norvegicus P11275
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-

Synonyms

Synonyms Comment Organism
calcium-calmodulin-dependent protein kinase II
-
 Rattus norvegicus
calcium-calmodulin-dependent protein kinase II
-
 Homo sapiens
CaMKIIalpha
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 Rattus norvegicus
CaMKIIbeta
-
 Rattus norvegicus
CaMKIIdeltaA
-
 Homo sapiens
CaMKIIgammaB
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Rattus norvegicus
8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function all CaMKII isoenzymes are implicated in a wide variety of cellular processes, which include a critical regulatory role in actin cytoskeletal assembly. All isoforms inhibit polymerization of actin in the order of decreasing effictivenes: CaMKIIbeta, CaMKIIgamma, CaMKIIdelta, CaMKIIalpha. Ca2+/CaM activation of all kinase isoforms produces a robust increase in actin polymerization that surpasses the rates of polymerization in the absence of kinase inhibition Rattus norvegicus
physiological function all CaMKII isoenzymes are implicated in a wide variety of cellular processes, which include a critical regulatory role in actin cytoskeletal assembly. All isoforms inhibit polymerization of actin in the order of decreasing effictivenes: CaMKIIbeta, CaMKIIgamma, CaMKIIdelta, CaMKIIalpha. Ca2+/CaM activation of all kinase isoforms produces a robust increase in actin polymerization that surpasses the rates of polymerization in the absence of kinase inhibition. The beta isoform bundles actin filaments and sequesters actin monomers in an activity-dependent manner Rattus norvegicus
physiological function all CaMKII isoenzymes are implicated in a wide variety of cellular processes, which include a critical regulatory role in actin cytoskeletal assembly. All isoforms inhibit polymerization of actin in the order of decreasing effictivenes: CaMKIIbeta, CaMKIIgamma, CaMKIIdelta, CaMKIIalpha. Ca2+/CaM activation of all kinase isoforms produces a robust increase in actin polymerization that surpasses the rates of polymerization in the absence of kinase inhibition. The delta isoform of CaMKII bundles F-actin filaments Homo sapiens
physiological function all CaMKII isoenzymes are implicated in a wide variety of cellular processes, which include a critical regulatory role in actin cytoskeletal assembly. All isoforms inhibit polymerization of actin in the order of decreasing effictivenes: CaMKIIbeta, CaMKIIgamma, CaMKIIdelta, CaMKIIalpha. Ca2+/CaM activation of all kinase isoforms produces a robust increase in actin polymerization that surpasses the rates of polymerization in the absence of kinase inhibition. The gamma isoform induces a layered structure in filaments Homo sapiens