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Literature summary for 2.7.11.17 extracted from
- Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II (2008), J. Pharmacol. Exp. Ther., 325, 267-275.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | blocking CaMKII or CaMKII-mediated signaling may offer a novel therapeutic target for the treatment of neuropathic pain | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-[N-(2-hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine | KN93 | Mus musculus |  |
| Trifluoperazine | - |
Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Mus musculus | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Mus musculus | ADP + a phosphoprotein | - |
? | |
| ATP + autocamtide-2 | substrate in activity assay | Mus musculus | ADP + phosphorylated autocamtide-2 | - |
? | |
| ATP + NMDA receptor | - |
Mus musculus | ADP + phosphorylated NMDA receptor | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2+/calmodulin-dependent protein kinase II | - |
Mus musculus |
| CaMKII | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
activity assay | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
activity assay | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | intraplantarly injected complete Freund's adjuvant, CFA, is found to induce spinal activity of CaMKII, blocked by KN93 | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | CaMKII is capable of regulating the activities of many ion channels and receptors | Mus musculus |
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Release 2023.1 (January 2023)
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