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Literature summary for 2.7.11.17 extracted from

  • Houston, C.M.; Hosie, A.M.; Smart, T.G.
    Distinct regulation of beta2 and beta3 subunit-containing cerebellar synaptic GABAA receptors by calcium/calmodulin-dependent protein kinase II (2008), J. Neurosci., 28, 7574-7584.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
A302R mutation impairs Ca2+/calmodulin-binding Rattus norvegicus
K42R mutation without enzymatic activity Rattus norvegicus
T286A the mutant is constitutively active and capable of only transient Ca2+-dependent activation Rattus norvegicus
T286D the mutant is constitutively active and Ca2+-independent Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
CaMK-II-Ntide specific CaMK-II inhibitory peptide Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ substrate activation, but not autophosphorylation dependent on Ca2+ Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus autophosphorylation is not dependent on calmodulin and Ca2+ ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
cerebellar granule cell
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GABA A receptor
-
 Rattus norvegicus ADP + phosphorylated GABA A receptor
-
 ?
additional information autophosphorylation is not dependent on calmodulin and Ca2+ Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha-calcium/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
alpha-CaMK-II
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
Calmodulin substrate activation, but not autophosphorylation is dependent on calmodulin Rattus norvegicus