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Literature summary for 2.7.11.17 extracted from

  • Ishida, A.; Sueyoshi, N.; Shigeri, Y.; Kameshita, I.
    Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases (2008), Br. J. Pharmacol., 154, 729-740.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine Ca2+/calmodulin-dependent protein kinases may be involved in cancer, cardiac hypertrophy, heart failure, arrhythmia, cardiomyocyte apoptosis, the regulation of higher order neuronal functions such as memory, learning disorder, Angelman's syndrome, Parkinson's disease, Alzheimer's disease, delayed neuronal death, diabetes, and osteoporosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AC3-I specific CaMKII inhibitor Homo sapiens
AIP specific CaMKII inhibitor Homo sapiens
CaMK phosphatase specifically dephosphorylates and regulates activity; specifically dephosphorylates and regulates activity; specifically dephosphorylates and regulates activity Homo sapiens
CaMKI (294-321) specific CaMKI inhibitor Homo sapiens
CaMKII (273-302) specific CaMKII inhibitor Homo sapiens
CaMKII (281-309) specific CaMKII inhibitor Homo sapiens
CaMKP phosphatase-N specifically dephosphorylates and regulates activity; specifically dephosphorylates and regulates activity; specifically dephosphorylates and regulates activity Homo sapiens
CN-21 specific CaMKII inhibitor Homo sapiens
KN-62 specific CaMK inhibitor; specific CaMK inhibitor; specific CaMK inhibitor Homo sapiens
KN-93 specific CaMK inhibitor; specific CaMK inhibitor; specific CaMK inhibitor Homo sapiens
PEP-19 specific CaMKII inhibitor Homo sapiens
protein phosphatase 1 negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation Homo sapiens
Protein phosphatase 2A negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation Homo sapiens
protein phosphatase 2B calcineurin, negative CaMK regulation by dephosphorylation; calcineurin, negative CaMK regulation by dephosphorylation; calcineurin, negative CaMK regulation by dephosphorylation Homo sapiens
protein phosphatase 2C negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation Homo sapiens
protein phosphatase M negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
nucleus
-
Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
isozyme CaMKI Homo sapiens
60000
-
isozyme CaMKIV Homo sapiens
550000
-
isozyme CaMKII Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q14012
-
-
Homo sapiens Q16566
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
heart
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + synapsin I
-
Homo sapiens ADP + phosphosynapsin I
-
?
additional information isozyme CaMKI is activated upon phosphorylation by CaMK kinase on Thr-177 located in activation loop Homo sapiens ?
-
?
additional information isozyme CaMKII is activated upon autophosphorylation on Thr-286 located in autoinhibitory domain Homo sapiens ?
-
?
additional information isozyme CaMKIV is activated upon phosphorylation by CaMK kinase on Thr-196 located in activation loop Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 40000, isozyme CaMKI Homo sapiens
monomer 1 * 60000, isozyme CaMKIV Homo sapiens
oligomer isozyme CaMKII Homo sapiens

Synonyms

Synonyms Comment Organism
CaMKI isozyme Homo sapiens
CaMKII isozyme Homo sapiens
CaMKIV isozyme Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
Calmodulin dependent on Homo sapiens