Application | Comment | Organism |
---|---|---|
medicine | Ca2+/calmodulin-dependent protein kinases may be involved in cancer, cardiac hypertrophy, heart failure, arrhythmia, cardiomyocyte apoptosis, the regulation of higher order neuronal functions such as memory, learning disorder, Angelman's syndrome, Parkinson's disease, Alzheimer's disease, delayed neuronal death, diabetes, and osteoporosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AC3-I | specific CaMKII inhibitor | Homo sapiens | |
AIP | specific CaMKII inhibitor | Homo sapiens | |
CaMK phosphatase | specifically dephosphorylates and regulates activity; specifically dephosphorylates and regulates activity; specifically dephosphorylates and regulates activity | Homo sapiens | |
CaMKI (294-321) | specific CaMKI inhibitor | Homo sapiens | |
CaMKII (273-302) | specific CaMKII inhibitor | Homo sapiens | |
CaMKII (281-309) | specific CaMKII inhibitor | Homo sapiens | |
CaMKP phosphatase-N | specifically dephosphorylates and regulates activity; specifically dephosphorylates and regulates activity; specifically dephosphorylates and regulates activity | Homo sapiens | |
CN-21 | specific CaMKII inhibitor | Homo sapiens | |
KN-62 | specific CaMK inhibitor; specific CaMK inhibitor; specific CaMK inhibitor | Homo sapiens | |
KN-93 | specific CaMK inhibitor; specific CaMK inhibitor; specific CaMK inhibitor | Homo sapiens | |
PEP-19 | specific CaMKII inhibitor | Homo sapiens | |
protein phosphatase 1 | negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation | Homo sapiens | |
Protein phosphatase 2A | negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation | Homo sapiens | |
protein phosphatase 2B | calcineurin, negative CaMK regulation by dephosphorylation; calcineurin, negative CaMK regulation by dephosphorylation; calcineurin, negative CaMK regulation by dephosphorylation | Homo sapiens | |
protein phosphatase 2C | negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation | Homo sapiens | |
protein phosphatase M | negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation; negative CaMK regulation by dephosphorylation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
isozyme CaMKI | Homo sapiens |
60000 | - |
isozyme CaMKIV | Homo sapiens |
550000 | - |
isozyme CaMKII | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q14012 | - |
- |
Homo sapiens | Q16566 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + synapsin I | - |
Homo sapiens | ADP + phosphosynapsin I | - |
? | |
additional information | isozyme CaMKI is activated upon phosphorylation by CaMK kinase on Thr-177 located in activation loop | Homo sapiens | ? | - |
? | |
additional information | isozyme CaMKII is activated upon autophosphorylation on Thr-286 located in autoinhibitory domain | Homo sapiens | ? | - |
? | |
additional information | isozyme CaMKIV is activated upon phosphorylation by CaMK kinase on Thr-196 located in activation loop | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 40000, isozyme CaMKI | Homo sapiens |
monomer | 1 * 60000, isozyme CaMKIV | Homo sapiens |
oligomer | isozyme CaMKII | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CaMKI | isozyme | Homo sapiens |
CaMKII | isozyme | Homo sapiens |
CaMKIV | isozyme | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
Calmodulin | dependent on | Homo sapiens |