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Literature summary for 2.7.11.17 extracted from

  • Said, M.; Becerra, R.; Palomeque, J.; Rinaldi, G.; Kaetzel, M.A.; Diaz-Sylvester, P.L.; Copello, J.A.; Dedman, J.R.; Mundina-Weilenmann, C.; Vittone, L.; Mattiazzi, A.
    Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H1669-H1683.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine arrhythmia is favored by CamKII activation during acidosis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
KN-93 0.001 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phospholamban
-
 Rattus norvegicus ADP + phosphorylated phospholamban
-
 ?
ATP + ryanodine receptor type 2
-
 Rattus norvegicus ADP + phosphorylated ryanodine receptor type 2
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
CaMKII
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
Calmodulin dependent on Rattus norvegicus