Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | required | Mus musculus | |
Calmodulin | required | Rattus norvegicus | |
additional information | brain-derived neurotrophic factor BDNF and nerve growth factor NGF increase the level of activated delta-CaMKII but not alpha-CaMKII, isozyme CaMKIIdelta can be activated by multiple pathways, including via p75 and TrkA, overview | Mus musculus | |
additional information | brain-derived neurotrophic factor BDNF and nerve growth factor NGF increase the level of activated delta-CaMKII but not alpha-CaMKII, isozyme CaMKIIdelta can be activated by multiple pathways, including via p75 and TrkA, overview | Rattus norvegicus | |
neurotrophins | have a regulatory role | Mus musculus | |
neurotrophins | have a regulatory role | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
K42M/T286D | inactive CaMKII mutant | Mus musculus |
K42M/T286D | inactive CaMKII mutant | Rattus norvegicus |
T286D | constitutively active CaMKII mutant | Mus musculus |
T286D | constitutively active CaMKII mutant | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | CaMKII isozymes have distinct cellular localizations and function | Mus musculus | - |
- |
additional information | CaMKII isozymes have distinct cellular localizations and function | Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Mus musculus | |
Ca2+ | required | Rattus norvegicus | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview | ? | - |
? | |
additional information | Rattus norvegicus | CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozymes CaMKII alpha, beta, gamma, and delta | - |
Rattus norvegicus | - |
isozymes CaMKII alpha, beta, gamma, and delta | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
cardiomyocyte | neonatal and posterior ventricular cardiac myocytes | Mus musculus | - |
cardiomyocyte | neonatal and posterior ventricular cardiac myocytes | Rattus norvegicus | - |
myocyte | - |
Mus musculus | - |
myocyte | - |
Rattus norvegicus | - |
neuron | neonatal mouse superior cervical ganglion neurons, cultured sympathetic neurons express alpha-, delta-, and gamma-, but not beta-CaMKII mRNA | Mus musculus | - |
neuron | neonatal mouse superior cervical ganglion neurons, cultured sympathetic neurons express alpha-, delta-, and gamma-, but not beta-CaMKII mRNA | Rattus norvegicus | - |
neuron | sympathetic | Mus musculus | - |
neuron | sympathetic | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview | Mus musculus | ? | - |
? | |
additional information | CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent protein kinase II | - |
Mus musculus |
calcium/calmodulin-dependent protein kinase II | - |
Rattus norvegicus |
CaMKII | - |
Mus musculus |
CaMKII | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Rattus norvegicus |