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Literature summary for 2.7.11.17 extracted from

  • Calderilla-Barbosa, L.; Ortega, A.; Cisneros, B.
    Phosphorylation of dystrophin Dp71d by Ca2+/calmodulin-dependent protein kinase II modulates the Dp71d nuclear localization in PC12 cells (2006), J. Neurochem., 98, 713-722.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
2-O-tetradecanoyl phorbol 13-acetate the activating effect is blocked by EGTA Rattus norvegicus
Calmodulin dependent on Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of CaMKII isozyme alpha and truncated mutant CaMKII/290 in PC-12 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of CaMKII favors the Dp71d nuclear accumulation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
KN62 a CaMKII-specific inhibitor Rattus norvegicus
N-(6-aminohexyl)-1-naphthalenesulfonamide i.e. W7, a calcium-calmodulin inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization Rattus norvegicus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, stimulation of calcium influx by cell depolarization increases Dp71d phosphorylation Rattus norvegicus
KCl KCl-induced cell depolarization stimulates Dp71d phosphorylation Rattus norvegicus
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + dystrophin Dp71d Rattus norvegicus the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization ADP + phosphorylated dystrophin Dp71d
-
 ?
additional information Rattus norvegicus CaMKII kinase modulates PC12 cell neuronal differentiation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell a pheochromocytoma cell line, NGF-induced Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + dystrophin Dp71d the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization Rattus norvegicus ADP + phosphorylated dystrophin Dp71d
-
 ?
ATP + dystrophin Dp71d a nuclear splicing isoform of Dp71, several potential sites for phosphorylation Rattus norvegicus ADP + phosphorylated dystrophin Dp71d
-
 ?
additional information CaMKII kinase modulates PC12 cell neuronal differentiation Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
CaMKII
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus