Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview | Rattus norvegicus | |
ionomycin | - |
Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression of GFP-tagged wild-type and mutant CaMKII in neuronal cultures and in HEK-293 cells, pH-dependent, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
I205K | site-directed mutagenesis, the mutant CaMKII does not undergo self-association in recombinant HEK-293 cells | Rattus norvegicus |
T286D | site-directed mutagenesis, the mutant CaMKII exhibits poor self-association in recombinant HEK-293 cells and is impaired in autophosphorylation | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | perinuclear, a nonsynaptic site | Rattus norvegicus | 5783 | - |
additional information | glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites | Rattus norvegicus | - |
- |
perinuclear space | endoplasmic reticulum | Rattus norvegicus | - |
- |
synapse | - |
Rattus norvegicus | 45202 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview | Rattus norvegicus | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
isozyme CaMKIIalpha | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | CaMKII is autophosphorylated at Thr286 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites | Rattus norvegicus | ? | - |
? | |
additional information | CaMKII performs autophosphorylation at Thr286 | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alphaCaMKII | - |
Rattus norvegicus |
Ca2+/calmodulin-dependent protein kinase II | - |
Rattus norvegicus |
CaMKII | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |