Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on | Mus musculus | |
Calmodulin | dependent on | Rattus norvegicus | |
additional information | activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory | Mus musculus | |
additional information | activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | has a regulatory function for CaMKI activity | Mus musculus | |
Ca2+ | has a regulatory function for CaMKI activity | Rattus norvegicus | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview | ? | - |
? | |
additional information | Rattus norvegicus | calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male C57BL/6 mice | - |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory | Mus musculus |
phosphoprotein | activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
hippocampus | neurons | Mus musculus | - |
hippocampus | neurons | Rattus norvegicus | - |
neuron | - |
Mus musculus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview | Mus musculus | ? | - |
? | |
additional information | calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calmodulin kinase I | - |
Mus musculus |
calmodulin kinase I | - |
Rattus norvegicus |
CaMKI | - |
Mus musculus |
CaMKI | - |
Rattus norvegicus |
CaMKII | - |
Mus musculus |
CaMKII | - |
Rattus norvegicus |
CaMKIV | - |
Mus musculus |
CaMKIV | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Rattus norvegicus |