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Literature summary for 2.7.11.17 extracted from

  • Mehren, J.E.; Griffith, L.C.
    Calcium-independent calcium/calmodulin-dependent protein kinase II in the adult Drosophila CNS enhances the training of pheromonal cues (2004), J. Neurosci., 24, 10584-10593.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin the unphosphorylated CaMK1 is dependent on Ca2+ and calmodulin, while the autophosphorylated enzyme is not Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
T287D site-directed mutagenesis, the Ca2+-independent mutant expression leads to reduced viability of flies, the toxic effect can be rescued by tetracycline, expression of the mutant in brain mushroom bodies does not affect the immediate memory, overview Drosophila melanogaster

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the unphosphorylated CaMK1 is dependent on Ca2+ and calmodulin, while the autophosphorylated enzyme is not Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster CaMKII is crucial for cellular and behavioral plasticity, autophosphorylation renders the enzyme independent on Ca2+ and calmodulin, which allows it to act as a molecular memory switch, CaMKII is required for memory formation of the brain in specific neurons, Ca2+-independent CaMKII mutant T287D in the adult Drosophila melanogaster CNS enhances plasticity and the training of pheromonal cues, mechanism, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme performs Ca2+/calmodulin-dependent autophosphorylation, which renders the enzyme independent on Ca2+ and calmodulin Drosophila melanogaster

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Drosophila melanogaster
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central nervous system
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 Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CaMKII is crucial for cellular and behavioral plasticity, autophosphorylation renders the enzyme independent on Ca2+ and calmodulin, which allows it to act as a molecular memory switch, CaMKII is required for memory formation of the brain in specific neurons, Ca2+-independent CaMKII mutant T287D in the adult Drosophila melanogaster CNS enhances plasticity and the training of pheromonal cues, mechanism, overview Drosophila melanogaster ?
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 ?

Synonyms

Synonyms Comment Organism
calcium-independent calcium/calmodulin-dependent protein kinase II
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 Drosophila melanogaster
calcium/calmodulin-dependent protein kinase II
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 Drosophila melanogaster
CaMKII
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 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Drosophila melanogaster