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Literature summary for 2.7.11.17 extracted from

  • Yamagata, Y.; Obata, K.
    Ca2+/calmodulin-dependent protein kinase II is reversibly autophosphorylated, inactivated and made sedimentable by acute neuronal excitation in rats in vivo (2004), J. Neurochem., 91, 745-754.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin kinase activity is dependent on Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
particle-bound particulate enzyme shows increased rate of inhibitory autophosphorylation during acute seizure in the brain induced by electroconvulsive treatment Rattus norvegicus
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-
soluble soluble enzyme shows decreased rate of inhibitory autophosphorylation during acute seizure in the brain induced by electroconvulsive treatment Rattus norvegicus
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-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ kinase activity is dependent on Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus CaMKII is reversibly, Ca2+/calmodulin-independently autophosphorylated at Thr286alpha and Thr287beta with inhibitory effect, inactivated and made sedimentable by acute neuronal excitation in rats in vivo, regulation, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male Wistar rats
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CaMKII performs reversible inhibitory, Ca2+/calmodulin-independent autophosphorylation at Thr286alpha and Thr287beta Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain hippocampus and parietal cortex Rattus norvegicus
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central nervous system
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 Rattus norvegicus
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hippocampus
-
 Rattus norvegicus
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neuron
-
 Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + PLRRTLSVAA-amide glycogen synthase-derived peptide GSP Rattus norvegicus ADP + phosphorylated PLRRTLSVAA-amide
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 ?
additional information CaMKII is reversibly, Ca2+/calmodulin-independently autophosphorylated at Thr286alpha and Thr287beta with inhibitory effect, inactivated and made sedimentable by acute neuronal excitation in rats in vivo, regulation, overview Rattus norvegicus ?
-
 ?
additional information CaMKII performs autophosphorylation Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
dimer alphabeta Rattus norvegicus

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase II
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 Rattus norvegicus
CaMKII
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus