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Literature summary for 2.7.11.17 extracted from
- Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2 (2005), J. Biol. Chem., 280, 35329-35336.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | dependent on | Mus musculus |  |
| Calmodulin | dependent on | Rattus norvegicus | |
| Calmodulin | dependent on | Sus scrofa | |
| Calmodulin | dependent on | Xenopus laevis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| synapse | dendritic CaMKII is dynamically targeted to the synapse | Rattus norvegicus | 45202 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Mus musculus | |
| Ca2+ | dependent on | Rattus norvegicus | |
| Ca2+ | dependent on | Sus scrofa | |
| Ca2+ | dependent on | Xenopus laevis | |
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Sus scrofa | |
| Mg2+ | - |
Xenopus laevis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | ? | - |
? | |
| additional information | Rattus norvegicus | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | ? | - |
? | |
| additional information | Sus scrofa | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | ? | - |
? | |
| additional information | Xenopus laevis | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
isozyme CaMKIIalpha | - |
| Rattus norvegicus | - |
isozyme CaMKIIalpha | - |
| Sus scrofa | - |
isozyme CaMKIIgammaB | - |
| Xenopus laevis | - |
isozyme CaMKIIbeta | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview | Mus musculus |
| phosphoprotein | isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview | Rattus norvegicus |
| phosphoprotein | isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview | Sus scrofa |
| phosphoprotein | isozyme CaMKIIalpha is autophosphorylated at Thr286 and Thr287 which allows it to bind to the C-terminal CaMKII-binding site at residues 819-894 of alpha-actinin-2, to residues 1260-1339 of receptor subunit NR2B, or to residues 1247-1495 of densin-180, overview | Xenopus laevis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| forebrain | - |
Rattus norvegicus | - |
| additional information | CaMKIIalpha is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | Mus musculus | ? | - |
? | |
| additional information | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | Rattus norvegicus | ? | - |
? | |
| additional information | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | Sus scrofa | ? | - |
? | |
| additional information | Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview | Xenopus laevis | ? | - |
? | |
| additional information | isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview | Mus musculus | ? | - |
? | |
| additional information | isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview | Rattus norvegicus | ? | - |
? | |
| additional information | isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview | Sus scrofa | ? | - |
? | |
| additional information | isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview | Xenopus laevis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calcium/calmodulin-dependent protein kinase II | - |
Mus musculus |
| calcium/calmodulin-dependent protein kinase II | - |
Rattus norvegicus |
| calcium/calmodulin-dependent protein kinase II | - |
Sus scrofa |
| calcium/calmodulin-dependent protein kinase IIbeta | - |
Xenopus laevis |
| CaMKIIalpha | - |
Mus musculus |
| CaMKIIalpha | - |
Rattus norvegicus |
| CaMKIIbeta | - |
Xenopus laevis |
| CaMKIIgammaB | - |
Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Mus musculus |
| 30 | - |
assay at | Rattus norvegicus |
| 30 | - |
assay at | Sus scrofa |
| 30 | - |
assay at | Xenopus laevis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
| 7.5 | - |
assay at | Rattus norvegicus |
| 7.5 | - |
assay at | Sus scrofa |
| 7.5 | - |
assay at | Xenopus laevis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Rattus norvegicus | |
| ATP | - |
Sus scrofa | |
| ATP | - |
Xenopus laevis | |
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