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Literature summary for 2.7.11.17 extracted from

  • Anderson, K.A.; Noeldner, P.K.; Reece, K.; Wadzinski, B.E.; Means, A.R.
    Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex (2004), J. Biol. Chem., 279, 31708-31716.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on, transient, tightly regulated Ca2+/calmodulin-dependent activation requiring phosphorylation at Thr200 by CaMK kinase, the Ca2+/calmodulin binding-autoinhibitory domain is required for interaction with protein phosphatase PP2A, binding of Ca2+/CaM and PP2A is exclusive, overview Mus musculus
ionomycin
-
 Mus musculus
additional information transient, tightly regulated Ca2+/calmodulin-dependent activation requiring phosphorylation at Thr200 by CaMK kinase, the Ca2+/calmodulin binding-autoinhibitory domain is required for interaction with protein phosphatase PP2A, binding of Ca2+/CaM and PP2A is exclusive, overview Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged CaMKIV in 293A cells Mus musculus

Protein Variants

Protein Variants Comment Organism
T200A site-directed mutagenesis, phosphorylation site mutant of CaMKIV, no activation by phosphorylation through CaMKK, no stimulation by ionomycin in absence of Ca2+ and calmodulin Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, transient, tightly regulated Ca2+/calmodulin-dependent activation requiring phosphorylation at Thr200 by CaMK kinase, the Ca2+/calmodulin binding-autoinhibitory domain is required for interaction with protein phosphatase PP2A, binding of Ca2+/CaM and PP2A is exclusive, overview Mus musculus
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cAMP response element-binding protein Mus musculus CaMKIV activates CREB by phosphorylation and stimulates CREB-mediated transcription ADP + phosphorylated cAMP response element-binding protein
-
 ?
additional information Mus musculus CaMKIV regulation, overview, CaMKIV functions as a potent stimulator of Ca2+-dependent gene expression ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein transient, tightly regulated Ca2+/calmodulin-dependent activation requiring phosphorylation at Thr200 by CaMK kinase, the Ca2+/calmodulin binding-autoinhibitory domain is required for interaction with protein phosphatase PP2A, binding of Ca2+/CaM and PP2A is exclusive, overview Mus musculus

Purification (Commentary)

Purification (Comment) Organism
recombinant FLAG-tagged CaMKIV from 293A cells by immunoaffinity chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cAMP response element-binding protein CaMKIV activates CREB by phosphorylation and stimulates CREB-mediated transcription Mus musculus ADP + phosphorylated cAMP response element-binding protein
-
 ?
ATP + cAMP response element-binding protein i.e. CREB Mus musculus ADP + phosphorylated cAMP response element-binding protein
-
 ?
ATP + PLRRTLSVAA
-
 Mus musculus ADP + ?
-
 ?
additional information CaMKIV regulation, overview, CaMKIV functions as a potent stimulator of Ca2+-dependent gene expression Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent protein kinase IV
-
 Mus musculus
calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex
-
 Mus musculus
CaMKIV
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus