Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on, transient, tightly regulated Ca2+/calmodulin-dependent activation requiring phosphorylation at Thr200 by CaMK kinase, the Ca2+/calmodulin binding-autoinhibitory domain is required for interaction with protein phosphatase PP2A, binding of Ca2+/CaM and PP2A is exclusive, overview | Mus musculus | |
ionomycin | - |
Mus musculus | |
additional information | transient, tightly regulated Ca2+/calmodulin-dependent activation requiring phosphorylation at Thr200 by CaMK kinase, the Ca2+/calmodulin binding-autoinhibitory domain is required for interaction with protein phosphatase PP2A, binding of Ca2+/CaM and PP2A is exclusive, overview | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of FLAG-tagged CaMKIV in 293A cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
T200A | site-directed mutagenesis, phosphorylation site mutant of CaMKIV, no activation by phosphorylation through CaMKK, no stimulation by ionomycin in absence of Ca2+ and calmodulin | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, transient, tightly regulated Ca2+/calmodulin-dependent activation requiring phosphorylation at Thr200 by CaMK kinase, the Ca2+/calmodulin binding-autoinhibitory domain is required for interaction with protein phosphatase PP2A, binding of Ca2+/CaM and PP2A is exclusive, overview | Mus musculus | |
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cAMP response element-binding protein | Mus musculus | CaMKIV activates CREB by phosphorylation and stimulates CREB-mediated transcription | ADP + phosphorylated cAMP response element-binding protein | - |
? | |
additional information | Mus musculus | CaMKIV regulation, overview, CaMKIV functions as a potent stimulator of Ca2+-dependent gene expression | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | transient, tightly regulated Ca2+/calmodulin-dependent activation requiring phosphorylation at Thr200 by CaMK kinase, the Ca2+/calmodulin binding-autoinhibitory domain is required for interaction with protein phosphatase PP2A, binding of Ca2+/CaM and PP2A is exclusive, overview | Mus musculus |
Purification (Comment) | Organism |
---|---|
recombinant FLAG-tagged CaMKIV from 293A cells by immunoaffinity chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cAMP response element-binding protein | CaMKIV activates CREB by phosphorylation and stimulates CREB-mediated transcription | Mus musculus | ADP + phosphorylated cAMP response element-binding protein | - |
? | |
ATP + cAMP response element-binding protein | i.e. CREB | Mus musculus | ADP + phosphorylated cAMP response element-binding protein | - |
? | |
ATP + PLRRTLSVAA | - |
Mus musculus | ADP + ? | - |
? | |
additional information | CaMKIV regulation, overview, CaMKIV functions as a potent stimulator of Ca2+-dependent gene expression | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent protein kinase IV | - |
Mus musculus |
calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex | - |
Mus musculus |
CaMKIV | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |