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Literature summary for 2.7.11.17 extracted from

  • Krymsky, M.A.; Chibalina, M.V.; Shirinsky, V.P.; Marston, S.B.; Vorotnikov, A.V.
    Evidence against the regulation of caldesmon inhibitory activity by p42/p44erk mitogen-activated protein kinase in vitro and demonstration of another caldesmon kinase in intact gizzard smooth muscle (1999), FEBS Lett., 452, 254-258.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
phorbol 12,13-dibutyrate induces an about 2fold maximum increase in caldesmon phosphorylation Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + caldesmon Gallus gallus caldesmon plays a role in the regulation of smooth muscle contraction ADP + caldesmon phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate p42/p44erk mitogen-activated protein kinase appears to be the major caldesmon kinase, but a yet unidentified kinase, rather than mitogen-activated protein kinase, may be involved in regulation of the caldesmon function in vivo Gallus gallus
a

Source Tissue

Source Tissue Comment Organism Textmining
gizzard smooth muscle Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + caldesmon
-
 Gallus gallus ADP + caldesmon phosphate
-
 ?
ATP + caldesmon caldesmon plays a role in the regulation of smooth muscle contraction Gallus gallus ADP + caldesmon phosphate
-
 ?