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Literature summary for 2.7.11.17 extracted from

  • Johnson, L.N.; Noble, M.E.M.; Owen, D.J.
    Active and inactive protein kinases: structural basis for regulation (1996), Cell, 85, 149-158.
    View publication on PubMed
Search for more literature for 2.7.11.17

Inhibitors

Inhibitors Comment Organism Structure
additional information autoinhibitory, in absence of Ca2+/calmodulin the enzyme shows an open conformation with extensive interactions between the C-terminal autoinhibitory sequence and the kinase core influencing the binding site for ATP Mammalia

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ binding required for activity Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mammalia the enzyme phosphorylates e.g. the synaptic vesicle-associated protein synapsin 1 and synapsin 2 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at Thr177 in the activation segment leads to activation Mammalia

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate catalytic aspartate residue Mammalia
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
ATP + a protein the enzyme phosphorylates e.g. the synaptic vesicle-associated protein synapsin 1 and synapsin 2 Mammalia ADP + a phosphoprotein
-
 ?

Subunits

Subunits Comment Organism
More the enzyme has an open, active conformation and a closed, inactive conformation Mammalia

Synonyms

Synonyms Comment Organism
CaMKI
-
 Mammalia

Cofactor

Cofactor Comment Organism Structure
ATP the ATP-binding site is influenced by the autoinhibitory conformation Mammalia
Calmodulin binding required for activity Mammalia