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Literature summary for 2.7.11.17 extracted from

  • Baudier, J.; Cole, R.D.
    Phosphorylation of tau proteins to a state like that in Alzheimers brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids (1987), J. Biol. Chem., 262, 17577-17583.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidic acid activating at low concentrations, inhibitory at high concentrations Rattus norvegicus
phosphatidylethanolamine activation Rattus norvegicus
phosphatidylserine activation, addition leads to 100% phosphorylation of tau2-protein Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
phosphatidic acid at high concentrations, activates at low concentrations Rattus norvegicus
phosphatidylinositol strong Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement Rattus norvegicus
Ca2+ requirement Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
x * 50000 + x * 60000, SDS-PAGE Rattus norvegicus
50000
-
x * 50000 + x * 60000, SDS-PAGE Bos taurus
60000
-
x * 50000 + x * 60000, SDS-PAGE Rattus norvegicus
60000
-
x * 50000 + x * 60000, SDS-PAGE Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
brain
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + microtubule-associated protein tau Ca2+/calmodulin dependent autophosphorylation Rattus norvegicus ?
-
?
ATP + microtubule-associated protein tau Ca2+/calmodulin dependent autophosphorylation Bos taurus ?
-
?
ATP + microtubule-associated protein tau all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation Rattus norvegicus ?
-
?
ATP + microtubule-associated protein tau all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation Bos taurus ?
-
?

Subunits

Subunits Comment Organism
? x * 50000 + x * 60000, SDS-PAGE Rattus norvegicus
? x * 50000 + x * 60000, SDS-PAGE Bos taurus

Cofactor

Cofactor Comment Organism Structure
Calmodulin requirement Rattus norvegicus
Calmodulin requirement Bos taurus