Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidic acid | activating at low concentrations, inhibitory at high concentrations | Rattus norvegicus | |
phosphatidylethanolamine | activation | Rattus norvegicus | |
phosphatidylserine | activation, addition leads to 100% phosphorylation of tau2-protein | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphatidic acid | at high concentrations, activates at low concentrations | Rattus norvegicus | |
phosphatidylinositol | strong | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | requirement | Rattus norvegicus | |
Ca2+ | requirement | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000 + x * 60000, SDS-PAGE | Rattus norvegicus |
50000 | - |
x * 50000 + x * 60000, SDS-PAGE | Bos taurus |
60000 | - |
x * 50000 + x * 60000, SDS-PAGE | Rattus norvegicus |
60000 | - |
x * 50000 + x * 60000, SDS-PAGE | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
brain | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + microtubule-associated protein tau | Ca2+/calmodulin dependent autophosphorylation | Rattus norvegicus | ? | - |
? | |
ATP + microtubule-associated protein tau | Ca2+/calmodulin dependent autophosphorylation | Bos taurus | ? | - |
? | |
ATP + microtubule-associated protein tau | all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation | Rattus norvegicus | ? | - |
? | |
ATP + microtubule-associated protein tau | all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000 + x * 60000, SDS-PAGE | Rattus norvegicus |
? | x * 50000 + x * 60000, SDS-PAGE | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | requirement | Rattus norvegicus | |
Calmodulin | requirement | Bos taurus |