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Literature summary for 2.7.11.16 extracted from

  • Packiriswamy, N.; Steury, M.; McCabe, I.C.; Fitzgerald, S.D.; Parameswaran, N.
    Bacterial dose-dependent role of G protein-coupled receptor kinase 5 in Escherichia coli-induced pneumonia (2016), Infect. Immun., 84, 1633-1641.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [G-protein-coupled receptor] Mus musculus
-
 ADP + [G-protein-coupled receptor]phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8VEB1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-
neutrophil from lung Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [G-protein-coupled receptor]
-
 Mus musculus ADP + [G-protein-coupled receptor]phosphate
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 5
-
 Mus musculus
GRK5
-
 Mus musculus

General Information

General Information Comment Organism
malfunction with a sublethal dose of Escherichia coli, GRK5 knockout mice exhibit higher plasma CXCL1/KC levels and enhanced lung neutrophil recruitment early after infection, and lower bacterial loads, than wild type mice. The inflammatory response is also diminished, and resolution of inflammation advanced, in the lungs of GRK5 knockout mice Mus musculus
physiological function GRK5 negatively regulates CXCL1/KC levels during bacterial pneumonia Mus musculus