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Literature summary for 2.7.11.16 extracted from

  • Chen, X.; Zhu, H.; Yuan, M.; Fu, J.; Zhou, Y.; Ma, L.
    G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis (2010), J. Biol. Chem., 285, 12823-12830.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.16

Protein Variants

Protein Variants Comment Organism
K215R a GRK5 kinase-dead mutant, fails to phosphorylate p53 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p53 + ATP
-
 Homo sapiens phosphorylated-p53 + ADP
-
 ?

Synonyms

Synonyms Comment Organism
GRK5
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of GRK5 in osteosarcoma cells inhibits DNAdamage-induced apoptosis via a p53-mediated mechanism Homo sapiens
malfunction transient overexpression of GRK5, but not kinase dead mutant K215R, results in a significant increase in p53 phosphorylation Homo sapiens
physiological function GRK5 phosphorylates p53 at Thr-55, which promotes the degradation of p53, leading to inhibition of p53-dependent apoptotic response to genotoxic damage Homo sapiens