Application | Comment | Organism |
---|---|---|
medicine | inhibition of GRK2 activity in osteoblasts as therapeutic strategy for increasing bone mass | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K220R | kinase-dead mutant | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ATP + G protein-coupled receptor | Homo sapiens | - |
ADP + phosphorylated G protein-coupled receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ATP + G protein-coupled receptor | - |
Homo sapiens | ADP + phosphorylated G protein-coupled receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor kinase 2 | - |
Homo sapiens |
GPCR kinase 2 | - |
Homo sapiens |
GRK2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of endogenous GRK2 enhances canonical signaling | Homo sapiens |
physiological function | GRK2 inhibits Wnt1-induced activation of a reporter construct and reduces Wnt3a-dependent stabilization and nuclear translocation of beta-catenin, | Homo sapiens |