Literature summary for 2.7.11.16 extracted from

Eijkelkamp, N.; Heijnen, C.J.; Elsenbruch, S.; Holtmann, G.; Schedlowski, M.; Kavelaars, A.
G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia (2008), Brain Behav. Immun., 23, 18-26.

Search for more literature for 2.7.11.16

Protein Variants

Protein Variants	Comment	Organism
additional information	capsaicin-induced referred hyperalgesia post-colitis is increased in GRK6-deficient mice compared to wild-type mice. However, referred hyperalgesia post-colitis is not affected by ablation of GRK6. GRK6 overexpression inhibits the in vitro sensitization of the capsaicin receptor TRPVI by interleukin 1beta, overview	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	G protein-coupled receptors are involved in regulating pain signaling in the context of inflammation. G protein-coupled receptor kinases modulate signaling through these receptors, GRK6 controls post-inflammatory visceral hyperalgesia, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O70293	female and male C57BL/6 mice	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	G protein-coupled receptors are involved in regulating pain signaling in the context of inflammation. G protein-coupled receptor kinases modulate signaling through these receptors, GRK6 controls post-inflammatory visceral hyperalgesia, overview	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
G protein-coupled receptor kinase 6	-	Mus musculus
GRK6	-	Mus musculus

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Release 2023.1 (January 2023)