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Literature summary for 2.7.11.16 extracted from

  • Tran, T.M.; Jorgensen, R.; Clark, R.B.
    Phosphorylation of the beta2-adrenergic receptor in plasma membranes by intrinsic GRK5 (2007), Biochemistry, 46, 14438-14449.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
isoproterenol stimulates the phosphorylation activity of GRK5 by10-15fold at 0.001 mM Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Calmodulin inhibits the phosphorylation of rhodopsin by GRK5 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [beta2-adrenergic receptor] Homo sapiens GRK5 plays a distinctive role in the phosphorylation of the beta2AR ADP + [beta2-adrenergic receptor] phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P34947
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification of GRK5 from HEK-293 cell membranes, separation from GRK2 and GRK6, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + rhodopsin cf. EC 2.7.11.14, rhodopsin is also a substrate of GRK5 Homo sapiens ADP + rhodopsin phosphate
-
?
ATP + [beta2-adrenergic receptor] GRK5 plays a distinctive role in the phosphorylation of the beta2AR Homo sapiens ADP + [beta2-adrenergic receptor] phosphate
-
?
ATP + [beta2-adrenergic receptor] cf. EC 2.7.11.15, recombinant FLAG-tagged beta2-adrenergic receptor stably expressed in HEK-293 cells Homo sapiens ADP + [beta2-adrenergic receptor] phosphate
-
?

Synonyms

Synonyms Comment Organism
GRK5
-
Homo sapiens
More cf. EC 2.7.11.15 and EC 2.7.11.14 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens