Literature summary for 2.7.11.16 extracted from

Keever, L.B.; Jones, J.E.; Andresen, B.T.
G protein-coupled receptor kinase 4gamma interacts with inactive GalphaS and Galpha13 (2008), Biochem. Biophys. Res. Commun., 367, 649-655.

Search for more literature for 2.7.11.16

Cloned(Commentary)

Cloned (Comment)	Organism
expression of GRK4gamma in 293T cells, which are devoid of endogenous GRK4gamma	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
K216M/K217M	a kinase-dead GRK4gamma mutant, that interacts with GalphaS and Galpha13 in the same way as the wild-type GRK4gamma	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P32298	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	GRK4 inhibits GalphaS-coupled GPCR signaling and lacks a PH domain, and GRK4gamma interacts with inactive GalphaS, inactive Gbeta, and inactive Galpha13, and to a lesser extent also with active GalphaS, subunits of heterotrimeric G proteins, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
G protein-coupled receptor kinase 4gamma	-	Homo sapiens
GPCR kinase 4	-	Homo sapiens
GRK4gamma	-	Homo sapiens

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Release 2023.1 (January 2023)