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Literature summary for 2.7.11.16 extracted from

  • Cohn, H.I.; Harris, D.M.; Pesant, S.; Pfeiffer, M.; Zhou, R.H.; Koch, W.J.; Dorn, G.W.; Eckhart, A.D.
    Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H1695-H1704.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
GRK2ct carboxylterminal portion of GRK2 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ATP + G protein-coupled receptor Mus musculus
-
 ADP + phosphorylated G protein-coupled receptor
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus Q99MK8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ATP + G protein-coupled receptor
-
 Mus musculus ADP + phosphorylated G protein-coupled receptor
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase
-
 Mus musculus
GRK2
-
 Mus musculus
GRK3
-
 Mus musculus
GRK5
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus GRK2 is increased in expression and activity in lymphocytes and vascular smooth muscle in human hypertension up

General Information

General Information Comment Organism
malfunction inhibition of vascular smooth muscle GRK2 enhances beta-adrenergic receptor signaling Mus musculus