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Literature summary for 2.7.11.16 extracted from

  • rawaka, S.; Wada, M.; Goto, S.; Karube, H.; Sakamoto, M.; Ren, C.H.; Koyama, S.; Nagasawa, H.; Kimura, H.; Kawanami, T.; Kurita, K.; Tajima, K.; Daimon, M.; Baba, M.; Kido, T.; Saino, S.; Goto, K.; Asao, H.; Kitanaka, C.; Takashita, E.; Hongo, S.; Nakamura, T.; Kayama, T.; Suzuki, Y.; Kobayashi, K.; Kat, K.a.t.a.
    The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinsons disease (2006), J. Neurosci., 26, 9227-9238.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene GRK5, co-expression with human alpha-synuclein in HEK-293 cells and co-localization in the plasma membrane, functional co-expression of GRK5 and alpha-synuclein in primary cortical neurons from the cerebral cortex of fetal mice Homo sapiens

Protein Variants

Protein Variants Comment Organism
K215R the GRK5 mutant binds to alpha-synuclein but does not phosphorylate it Homo sapiens
additional information haplotypic association of the GRK5 gene with susceptibility to sporadic Parkinson's disease, the haplotype contains two functional single-nucleotide polymorphisms, m22.1 and m24, in introns of the GRK5 gene, which bind to Yin Yang-1, YY1, and cAMP response element-binding protein 1, CREB-1, respectively, and increases transcriptional activity of the reporter gene, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + alpha-synuclein Homo sapiens GRK5 phosphorylates Ser-129 of alpha-synuclein at the plasma membrane and induces translocation of phosphorylated alpha-synuclein to the perikaryal area, GRK5 promotes alpha-linolenic acid-induced oligomerization of alpha-synuclein, alpha-synuclein phosphorylation by GRK5 plays a crucial role in the pathogenesis of sporadic Parkinson's disease, sPD ADP + phosphorylated alpha-synuclein
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain GRK5 accumulates in Lewy bodies and colocalizes with alpha-synuclein in the pathological structures of the brains of sporadic Parkinson's disease patients Homo sapiens
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neuron
-
 Homo sapiens
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substantia nigra
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha-synuclein GRK5 phosphorylates Ser-129 of alpha-synuclein at the plasma membrane and induces translocation of phosphorylated alpha-synuclein to the perikaryal area, GRK5 promotes alpha-linolenic acid-induced oligomerization of alpha-synuclein, alpha-synuclein phosphorylation by GRK5 plays a crucial role in the pathogenesis of sporadic Parkinson's disease, sPD Homo sapiens ADP + phosphorylated alpha-synuclein
-
 ?
ATP + alpha-synuclein phosphorylation at Ser129 Homo sapiens ADP + phosphorylated alpha-synuclein
-
 ?

Synonyms

Synonyms Comment Organism
G-protein-coupled receptor kinase 5
-
 Homo sapiens
GRK5
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens