Inhibitors | Comment | Organism | Structure |
---|---|---|---|
heparin | inhibits GRK6 | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dopamine D1 receptor | Rattus norvegicus | dopamine D1 receptors in IEC-6 rapidly desensitize to D1-like agonist stimulation and GRK 6 isozymes A and B, but not GRK 4, appear to be involved in agonist-mediated responsiveness and desensitization | ADP + phosphorylated dopamine D1 receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
isozyme GRK6 A and GRK6 B | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
crypt | - |
Rattus norvegicus | - |
IEC-6 cell | intestinal epithelial cell line | Rattus norvegicus | - |
villus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dopamine D1 receptor | - |
Rattus norvegicus | ADP + phosphorylated dopamine D1 receptor | - |
? | |
ATP + dopamine D1 receptor | dopamine D1 receptors in IEC-6 rapidly desensitize to D1-like agonist stimulation and GRK 6 isozymes A and B, but not GRK 4, appear to be involved in agonist-mediated responsiveness and desensitization | Rattus norvegicus | ADP + phosphorylated dopamine D1 receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
by G protein-coupled receptor kinase 6 | - |
Rattus norvegicus |
GRK6 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |