Literature summary for 2.7.11.16 extracted from

Zhu, H.; Lu, Y.; Wang, X.; Treiber, F.A.; Harshfield, G.A.; Snieder, H.; Dong, Y.
The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins (2006), Am. J. Hypertens., 19, 61-66.

Search for more literature for 2.7.11.16

Cloned(Commentary)

Cloned (Comment)	Organism
GRK4, DNA and amino acid sequence determination of polymorphisms, genotyping of American twins	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A142V	naturally occuring functional polymorphism, the mutation leads to increased GRK4 activity and phosphorylation of dopamine receptors, phenotype	Homo sapiens
A486V	naturally occuring functional polymorphism, the mutation leads to increased GRK4 activity and phosphorylation of dopamine receptors, phenotype	Homo sapiens
R65L	naturally occuring functional polymorphism, the mutation leads to increased GRK4 activity and phosphorylation of dopamine receptors, the mutation plays a role in blood pressure regulation in adolescents and young adults, phenotype	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	GRK4 is involved in activity of dopamine receptors in renal proximal tubules and mediates sodium reabsorption and blood pressure regulation	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	Americans	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	GRK4 is involved in activity of dopamine receptors in renal proximal tubules and mediates sodium reabsorption and blood pressure regulation	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
G protein-coupled receptor kinase 4	-	Homo sapiens
GRK4	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)