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Literature summary for 2.7.11.16 extracted from

  • Neve, K.A.
    Novel features of G protein-coupled receptor kinase 4 (2006), Mol. Pharmacol., 69, 673-676.
    View publication on PubMed
Search for more literature for 2.7.11.16

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of isozyme GRK4gamma and dopamine D1 receptor in HEK-293 cells leads to phosphorylation of the receptor by GRK4, this effect is not seen with isozyme GRK4beta and GRK4delta Homo sapiens

Protein Variants

Protein Variants Comment Organism
A142V expression of the GRK4gamma mutant in transgenic mice leads to development of hypertension and lack of D1 agonist-induced diuresis and natriuresis in the mice Homo sapiens
R65L/A142V/A486V co-expression in CHO cells with the dopamine D1 receptor causes enhanced desensitization and agonist-independent phosphorylation of the receptor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane anchoring of GRK4 by palmitoyl residue at the C-terminus Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [dopamine D1 receptor] Homo sapiens GRK4 constitutively phosphorylates active and inactive receptor, in the latter case diminishing stimulation of the receptor by dopamine, phosphorylation reduces receptor desensitization and internalization, followed by reduced cAMP accumulation ADP + [dopamine D1 receptor]phosphate
-
 ?
ATP + [G protein-coupled receptor] Homo sapiens GRK4-6 ADP + [G protein-coupled receptor]phosphate
-
 ?
additional information Homo sapiens the GRK4 isozymes are differentially regulated, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 4 splicing variants of GRK4, i.e. GRK4alpha, GRK4beta, GRK4gamma, and GRK4delta, overview
-

Posttranslational Modification

Posttranslational Modification Comment Organism
lipoprotein GRK4 is palmitoylated at the C-terminus Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [beta2-adrenergic receptor] GRK4-6 Homo sapiens ADP + [beta2-adrenergic receptor]phosphate
-
 ?
ATP + [dopamine D1 receptor] GRK4 constitutively phosphorylates active and inactive receptor, in the latter case diminishing stimulation of the receptor by dopamine, phosphorylation reduces receptor desensitization and internalization, followed by reduced cAMP accumulation Homo sapiens ADP + [dopamine D1 receptor]phosphate
-
 ?
ATP + [dopamine D1 receptor] GRK4 phosphorylates active and inactive receptor Homo sapiens ADP + [dopamine D1 receptor]phosphate
-
 ?
ATP + [follicle-stimulating hormone receptor] GRK4-6 Homo sapiens ADP + [follicle-stimulating hormone receptor]phosphate
-
 ?
ATP + [G protein-coupled receptor] GRK4-6 Homo sapiens ADP + [G protein-coupled receptor]phosphate
-
 ?
ATP + [luteinizing hormone/chorionic gonadotropin receptor] GRK4-6 Homo sapiens ADP + [luteinizing hormone/chorionic gonadotropin receptor]phosphate
-
 ?
ATP + [M2 muscarinic receptor] GRK4-6 Homo sapiens ADP + [M2 muscarinic receptor]phosphate
-
 ?
ATP + [rhodopsin] GRK4-6 Homo sapiens ADP + [rhodopsin]phosphate
-
 ?
additional information the GRK4 isozymes are differentially regulated, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 4
-
 Homo sapiens
GRK4
-
 Homo sapiens
More GRK4 belongs to the GRK4 subfamily of the GRK family Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens