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Literature summary for 2.7.11.16 extracted from

  • Picascia, A.; Capobianco, L.; Iacovelli, L.; De Blasi, A.
    Analysis of differential modulatory activities of GRK2 and GRK4 on Galphaq-coupled receptor signaling (2004), Methods Enzymol., 390, 337-353.
    View publication on PubMed
Search for more literature for 2.7.11.16

Activating Compound

Activating Compound Comment Organism Structure
additional information no interaction with G protein Gbetagamma subunits by GRK4, which contains no N-terminal RGS domain Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of kinase-dead GRK4 mutant in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K216M/K217M site-directed mutagenesis, kinase-dead GRK4 mutant, overexpression in HEK-293 cells leads to partially desensitization of GPCR Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane anchoring via palmitoylation Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in GPCR signal transduction pathways and desensitization ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 4 splicing variants of GRK4
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate specificity Homo sapiens ?
-
 ?
additional information the enzyme is involved in GPCR signal transduction pathways and desensitization Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More GRK family domain structure Homo sapiens

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 4
-
 Homo sapiens
GPCR kinase
-
 Homo sapiens
GRK4
-
 Homo sapiens
More the enzyme belongs to the GRK4 subfamily of the GRK family Homo sapiens