Literature summary for 2.7.11.16 extracted from

Keys, J.R.; Zhou, R.H.; Harris, D.M.; Druckman, C.A.; Eckhart, A.D.
Vascular smooth muscle overexpression of G protein-coupled receptor kinase 5 elevates blood pressure, which segregates with sex and is dependent on Gi-mediated signaling (2005), Circulation, 112, 1145-1153.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene encoding GRK5 with SM22alpha promoter for construction of transgenic mice expressing the enzyme in vascular smooth muscle	Bos taurus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of transgenic mice overexpressing GRK5 2fold in vascular smooth muscle leading to hypertension in the mutant mice with a 25-35% increase in blood pressure, which segregates with sex, male show higher blood pressure than female mice, and is dependent on Gi-mediated signaling, inhibition of the latter by pertussis toxin or inhibition of beta1-adrenergic receptor activity restore blood pressure to normal level	Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Bos taurus	GRK5 elevates blood pressure in vascular smooth muscle via Gi signaling involing the beta1-adrenergic receptor, mechanism overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	GRK5 elevates blood pressure in vascular smooth muscle via Gi signaling involing the beta1-adrenergic receptor, mechanism overview	Bos taurus	?	-	?

Synonyms

Synonyms	Comment	Organism
G protein-coupled receptor kinase 5	-	Bos taurus
GRK5	-	Bos taurus

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Release 2023.1 (January 2023)