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Literature summary for 2.7.11.16 extracted from

  • Sallese, M.; Mariggio, S.; Collodel, G.; Moretti, E.; Piomboni, P.; Baccetti, B.; De Blasi, A.
    G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells (1997), J. Biol. Chem., 272, 10188-10195.
    View publication on PubMed
Search for more literature for 2.7.11.16

Inhibitors

Inhibitors Comment Organism Structure
Calmodulin reaction of isoenzyme GRK4alpha with rhodopsin, IC50: 80 nM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme is involved in fertilization ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P32298 4 isoforms: GRK4alpha, GRK4beta, GRK4gamma, GRK4delta
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture spermatogonia cell line GC-1 spg Homo sapiens
-
germ
-
 Homo sapiens
-
sperm GRK4gamma is the only detectable isoform in human sperm Homo sapiens
-
spermatozoon
-
 Homo sapiens
-
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + rhodopsin reaction only with GRK4alpha isoform, no reaction with GRK4beta, GRK4gamma, GRK4delta Homo sapiens ADP + phosphorylated rhodopsin
-
 ?
additional information enzyme is involved in fertilization Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase GRK4
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00008
-
 reaction of isoenzyme GRK4alpha with rhodopsin, IC50: 80 nM Homo sapiens Calmodulin