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Literature summary for 2.7.11.15 extracted from

  • Martini, J.S.; Raake, P.; Vinge, L.E.; DeGeorge, B.; Chuprun, J.K.; Harris, D.M.; Gao, E.; Eckhart, A.D.; Pitcher, J.A.; Koch, W.J.
    Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes (2008), Proc. Natl. Acad. Sci. USA, 105, 12457-12462.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information cardiac GRK2 overexpression does not augments hypertrophy in vivo, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
additional information GRK2 is not located in the nucleus Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus GRK2 is important for myocardial regulation, and is up-regulated in the dysfunctional heart ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q3UYH7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GRK2 is important for myocardial regulation, and is up-regulated in the dysfunctional heart Mus musculus ?
-
 ?
additional information no activity of GRK2 with alpha1-adrenergic receptor. GRK2 does not show class II histone deacetylase kinase activity or interaction with histone deacetylase kinases in vivo Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
GRK2
-
 Mus musculus