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Literature summary for 2.7.11.15 extracted from

  • Cohn, H.I.; Harris, D.M.; Pesant, S.; Pfeiffer, M.; Zhou, R.H.; Koch, W.J.; Dorn, G.W.; Eckhart, A.D.
    Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H1695-H1704.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of GRK2, with or without inhibitor GRK2ct, in vascular smooth emuscle of transgenic mice, phenotypes, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GRK2ct C-terminal portion of GRK2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + alpha1D-adrenergic receptor Homo sapiens inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction and signalling, overview ADP + alpha1D-adrenergic receptor phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P25098
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
lymphocyte GRK2 is increased in hypertension Homo sapiens
-
vascular smooth muscle GRK2 is increased in hypertension Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha1D-adrenergic receptor
-
 Homo sapiens ADP + alpha1D-adrenergic receptor phosphate
-
 ?
ATP + alpha1D-adrenergic receptor inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction and signalling, overview Homo sapiens ADP + alpha1D-adrenergic receptor phosphate
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 2
-
 Homo sapiens
GRK2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens