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Literature summary for 2.7.11.15 extracted from
- Insulin causes renal dopamine D1 receptor desensitization via GRK2-mediated receptor phosphorylation involving phosphatidylinositol 3-kinase and protein kinase C (2007), Am. J. Physiol. Renal Physiol., 293, F877-F884.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Insulin | leads to increase dopamine D1 receptor serine phosphorylation by GRK2 | Didelphis virginiana |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | expression of GRK2-specific siRNA leads to downregulation of the enzyme | Didelphis virginiana |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | insulin causes GRK2 translocation to the membranes, which is blocked by genistein, wortmannin, chelerythrine chloride, and GRK2-specific siRNA | Didelphis virginiana | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Didelphis virginiana |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + dopamine D1 receptor | Didelphis virginiana | phosphorylation by GRK2 has a regulatory role as part of the PI3K-PKC-GRK2 cascade | ADP + phosphorylated dopamine D1 receptor | - |
? | |
| additional information | Didelphis virginiana | insulin-mediated dopamine D1 receptor desensitization and underlying molecular mechanism in opossum kidney cells, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Didelphis virginiana | O97627 | North American opossum, gene GRK2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Didelphis virginiana | - |
| kidney | - |
Didelphis virginiana | - |
| OK cell | a renal proximal tubular cell line | Didelphis virginiana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + dopamine D1 receptor | phosphorylation by GRK2 has a regulatory role as part of the PI3K-PKC-GRK2 cascade | Didelphis virginiana | ADP + phosphorylated dopamine D1 receptor | - |
? | |
| ATP + dopamine D1 receptor | hyperserine phosphorylation by GRK2 | Didelphis virginiana | ADP + phosphorylated dopamine D1 receptor | - |
? | |
| additional information | insulin-mediated dopamine D1 receptor desensitization and underlying molecular mechanism in opossum kidney cells, overview | Didelphis virginiana | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G protein-coupled receptor kinase 2 | - |
Didelphis virginiana |
| GRK2 | - |
Didelphis virginiana |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Didelphis virginiana | |
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Release 2023.1 (January 2023)
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