Literature summary for 2.7.11.15 extracted from

Lodowski, D.T.; Pitcher, J.A.; Capel, W.D.; Lefkowitz, R.J.; Tesmer, J.J.
Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma (2003), Science, 300, 1256-1262.

Search for more literature for 2.7.11.15

Activating Compound

Activating Compound	Comment	Organism	Structure
G protein	GRK2 binds G protein beta1gamma2 subunits, binding structure, overview	Bos taurus

Cloned(Commentary)

Cloned (Comment)	Organism
co-overexpression of GRK2 and G protein beta1gamma2 subunits in Spodoptera frugiperda Sf9 cells using the baculovirus infection system	Bos taurus

Crystallization (Commentary)

Crystallization (Comment)	Organism
purified recombinant GRK2 in complex with purified recombinant G protein beta1gamma2 subunits, X-ray diffraction structure determination and analysis at 2.5 A resolution, modeling	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	associated, GRK2 in complex with G protein beta1gamma2 subunits	Bos taurus	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Bos taurus	phosphorylation of heptahelical receptors by GRK2 is a universal regulatory mehanism leading to desensitization of G protein signaling and to the activation of alternative signaling pathways	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor]	substrate and activator binding site structure, active site structure, structure-function relationship, overview	Bos taurus	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	phosphorylation of heptahelical receptors by GRK2 is a universal regulatory mehanism leading to desensitization of G protein signaling and to the activation of alternative signaling pathways	Bos taurus	?	-	?
additional information	the enzyme contains regulatory sites for Ca2+/calmodulin, protein kinase C, and clathrin	Bos taurus	?	-	?

Subunits

Subunits	Comment	Organism
More	GRK2 consists of 3 modular domains: a predominantly N-terminal RGS homology domain, a central protein kinase domain, and a C-terminal pleckstrin homology domain, domain functions, overview	Bos taurus

Synonyms

Synonyms	Comment	Organism
G protein-coupled receptor kinase 2	-	Bos taurus
GRK2	-	Bos taurus
guanine nucleotide-binding protein-coupled receptor kinase	-	Bos taurus

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Release 2023.1 (January 2023)