Literature summary for 2.7.11.15 extracted from

Usui, I.; Imamura, T.; Babendure, J.L.; Satoh, H.; Lu, J.C.; Hupfeld, C.J.; Olefsky, J.M.
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes (2005), Mol. Endocrinol., 19, 2760-2768.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of wild-type and kinase-dead mutant GRK2 in murine 3T3-L1 adipocytes via adenovirus infection system leading to inhibition of Galphaq/11 signaling, including tyrosine phosphorylation of Galphaq11 and cdc42-associated phosphatidylinositol 3-kinase activity, overexpression of the inactive muant, but not of wild-type enzyme, inhibits endothelin-1-induced Ser612 phosphorylation of insulin receptor substrate-1, and restores activation of the pathway	Homo sapiens

Cloned (Comment)

Organism

overexpression of wild-type and kinase-dead mutant GRK2 in murine 3T3-L1 adipocytes via adenovirus infection system leading to inhibition of Galphaq/11 signaling, including tyrosine phosphorylation of Galphaq11 and cdc42-associated phosphatidylinositol 3-kinase activity, overexpression of the inactive muant, but not of wild-type enzyme, inhibits endothelin-1-induced Ser612 phosphorylation of insulin receptor substrate-1, and restores activation of the pathway

Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + G protein-coupled receptor	Homo sapiens	-	ADP + phosphorylated G protein-coupled receptor	-	?
additional information	Homo sapiens	GRK2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes, GRK2 does not affect insulin receptor tyrosine phosphorylation	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
ATP + G protein-coupled receptor	-	Homo sapiens	ADP + phosphorylated G protein-coupled receptor	-	?
additional information	GRK2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes, GRK2 does not affect insulin receptor tyrosine phosphorylation	Homo sapiens	?	-	?
additional information	GRK2 interacts by direct binding with Galphaq/11, phosphorylation of agonist-activated seven-transmembrane receptors by GRK2	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
G protein-coupled receptor kinase 2	-	Homo sapiens
GRK2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens