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Literature summary for 2.7.11.15 extracted from
- Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2 (2004), J. Histochem. Cytochem., 52, 759-767.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + beta2-adrenergic receptor | Rattus norvegicus | desensitization of the receptor with subsequent decline in the stimulatory effects of beta2-adrenergic agonists over time, the receptor is involved in alveolar Na+ and water clearance | ADP + phosphorylated beta2-adrenergic receptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| alveolar cell type I | i.e. AT1 cells, from transdifferentiation of AT2 cells | Rattus norvegicus | - |
| alveolar cell type II | i.e. AT2 cells, primary cells, transdifferentiation to AT1 cells | Rattus norvegicus | - |
| epithelium | analysis of GRK2 localization in alveolar epithelium | Rattus norvegicus | - |
| lung | analysis of GRK2 localization in alveolar epithelium, determination of expression level | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + beta2-adrenergic receptor | - |
Rattus norvegicus | ADP + phosphorylated beta2-adrenergic receptor | - |
? | |
| ATP + beta2-adrenergic receptor | desensitization of the receptor with subsequent decline in the stimulatory effects of beta2-adrenergic agonists over time, the receptor is involved in alveolar Na+ and water clearance | Rattus norvegicus | ADP + phosphorylated beta2-adrenergic receptor | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G-protein receptor kinase 2 | - |
Rattus norvegicus |
| GRK2 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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