Any feedback?
Literature summary for 2.7.11.15 extracted from
- G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation (2005), J. Biol. Chem., 280, 12774-12780.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| beta-arrestin2 | mediates GRK activity, forms a signaling complex with filamin and dopamine D3 receptor, interactions, overview | Bos taurus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of GRK2 in HEK-293 cells and in COS-7 cells, co-expression with FLAG-tagged dopamine D3 receptor, and filamin A and/or beta-arrestin, recombinant beta-arrestin is accumulated in the plasma membrane in presence of GRK2 and absence of agonist | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| quinpirole | inhibits GRK2 and GRK3 | Bos taurus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + dopamine D3 receptor | Bos taurus | the receptor is activated by GRK2 and GRK3 phosphorylation involving beta-arrestins, GRK-mediated regulation of receptor-filamin complex stability and receptor-G protein signaling potential, GRK2 reduces the dopamine D3 receptor signaling, overview | ADP + phosphorylated dopamine D3 receptor | - |
? | |
| additional information | Bos taurus | dopamine D3 receptor binds to G proteins, the coupling is regulated by the filamin expression level | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + dopamine D3 receptor | - |
Bos taurus | ADP + phosphorylated dopamine D3 receptor | - |
? | |
| ATP + dopamine D3 receptor | the receptor is activated by GRK2 and GRK3 phosphorylation involving beta-arrestins, GRK-mediated regulation of receptor-filamin complex stability and receptor-G protein signaling potential, GRK2 reduces the dopamine D3 receptor signaling, overview | Bos taurus | ADP + phosphorylated dopamine D3 receptor | - |
? | |
| additional information | dopamine D3 receptor binds to G proteins, the coupling is regulated by the filamin expression level | Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G protein-coupled receptor kinase 2 | - |
Bos taurus |
| G protein-coupled receptor kinase 3 | - |
Bos taurus |
| GRK2 | - |
Bos taurus |
| GRK3 | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Bos taurus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Bos taurus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
