Activating Compound | Comment | Organism | Structure |
---|---|---|---|
G protein | binding and modulation of GRK2 and GRK3, Gbetagamma subunits bind GRK2 required for lipid association and G protein-coupled receptor phosphorylation and are released afterwards | Mus musculus | |
G protein | binding and modulation of GRK2 and GRK3, Gbetagamma subunits bind GRK2 required for lipid association and G protein-coupled receptor phosphorylation and are released afterwards | Homo sapiens | |
G protein | binding and modulation of GRK2 and GRK3, Gbetagamma subunits bind GRK2 required for lipid association and G protein-coupled receptor phosphorylation and are released afterwards | Rattus norvegicus | |
additional information | phosphorylation by c-Src activates GRK2 | Mus musculus | |
additional information | phosphorylation by c-Src activates GRK2 | Homo sapiens | |
additional information | phosphorylation by c-Src activates GRK2 | Rattus norvegicus | |
phosphatidylinositol 4,5-bisphosphate | binding of GRK2 and GRK3 via their pleckstrin homology domains, activate the phosphorylation activity | Mus musculus | |
phosphatidylinositol 4,5-bisphosphate | binding of GRK2 and GRK3 via their pleckstrin homology domains, activate the phosphorylation activity | Homo sapiens | |
phosphatidylinositol 4,5-bisphosphate | binding of GRK2 and GRK3 via their pleckstrin homology domains, activate the phosphorylation activity | Rattus norvegicus | |
phosphatidylserine | binding of GRK2 and GRK3 via their pleckstrin homology domains, activate the phosphorylation activity | Mus musculus | |
phosphatidylserine | binding of GRK2 and GRK3 via their pleckstrin homology domains, activate the phosphorylation activity | Homo sapiens | |
phosphatidylserine | binding of GRK2 and GRK3 via their pleckstrin homology domains, activate the phosphorylation activity | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of transgenic tissue specific or knockout mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actinin | inhibits GRK2 | Homo sapiens | |
actinin | inhibits GRK2 | Mus musculus | |
actinin | inhibits GRK2 | Rattus norvegicus | |
Ca2+ | inhibits GRK2 | Rattus norvegicus | |
Calmodulin | inhibits GRK2 | Homo sapiens | |
Calmodulin | inhibits GRK2 | Mus musculus | |
Calmodulin | inhibits GRK2 | Rattus norvegicus | |
caveolin | microsomal anchor protein, inhibits GRK2 | Homo sapiens | |
caveolin | microsomal anchor protein, inhibits GRK2 | Mus musculus | |
caveolin | microsomal anchor protein, inhibits GRK2 | Rattus norvegicus | |
additional information | phosphorylation by ERK1/2 inhibits GRK2 | Homo sapiens | |
additional information | phosphorylation by ERK1/2 inhibits GRK2 | Mus musculus | |
additional information | phosphorylation by ERK1/2 inhibits GRK2 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | GRK2 and GRK3 | Mus musculus | 5737 | - |
cytoplasm | GRK2 and GRK3 | Homo sapiens | 5737 | - |
cytoplasm | GRK2 and GRK3 | Rattus norvegicus | 5737 | - |
plasma membrane | GRK2 and GRK3, transient translocation upon G protein-coupled receptor activation | Mus musculus | 5886 | - |
plasma membrane | GRK2 and GRK3, transient translocation upon G protein-coupled receptor activation | Homo sapiens | 5886 | - |
plasma membrane | GRK2 and GRK3, transient translocation upon G protein-coupled receptor activation | Rattus norvegicus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | inhibits GRK2 | Mus musculus | |
Ca2+ | inhibits GRK2 | Homo sapiens | |
Ca2+ | inhibits GRK2 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + G protein-coupled receptor | Mus musculus | regulation mechanism of GRK2, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview | ADP + phosphorylated G protein-coupled receptor | - |
? | |
ATP + G protein-coupled receptor | Homo sapiens | regulation mechanism of GRK2, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview | ADP + phosphorylated G protein-coupled receptor | - |
? | |
ATP + G protein-coupled receptor | Rattus norvegicus | regulation mechanism of GRK2, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview | ADP + phosphorylated G protein-coupled receptor | - |
? | |
additional information | Mus musculus | GRKs are involved in diverse physiological processes and pathologies, overview | ? | - |
? | |
additional information | Homo sapiens | GRKs are involved in diverse physiological processes and pathologies, overview | ? | - |
? | |
additional information | Rattus norvegicus | GRKs are involved in diverse physiological processes and pathologies, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | mechanisms of regulation of GRK protein stability and degradation, e.g. via ubiquination or protease cleavage, overview | Rattus norvegicus |
additional information | mechanisms of regulation of GRK protein stability and degradation, e.g. via ubiquitination or protease cleavage, overview | Mus musculus |
additional information | mechanisms of regulation of GRK protein stability and degradation, e.g. via ubiquitination or protease cleavage, overview | Homo sapiens |
phosphoprotein | GRK2 is phosphorylated by c-Src kinase, ERK1 and ERK2, protein kinase C, and PKA, overview | Mus musculus |
phosphoprotein | GRK2 is phosphorylated by c-Src kinase, ERK1 and ERK2, protein kinase C, and PKA, overview | Homo sapiens |
phosphoprotein | GRK2 is phosphorylated by c-Src kinase, ERK1 and ERK2, protein kinase C, and PKA, overview | Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] | regulation mechanism | Mus musculus | |
ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] | regulation mechanism | Homo sapiens | |
ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] | regulation mechanism | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
additional information | GRK2 and GRK3 are expressed in a wide variety of tissues, expression patterns, overview | Mus musculus | - |
additional information | GRK2 and GRK3 are expressed in a wide variety of tissues, expression patterns, overview | Homo sapiens | - |
additional information | GRK2 and GRK3 are expressed in a wide variety of tissues, expression patterns, overview | Rattus norvegicus | - |
myelomonocytic leukemia cell | GRK2 | Mus musculus | - |
myelomonocytic leukemia cell | GRK2 | Homo sapiens | - |
myelomonocytic leukemia cell | GRK2 | Rattus norvegicus | - |
T-lymphocyte | - |
Mus musculus | - |
T-lymphocyte | - |
Homo sapiens | - |
T-lymphocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + G protein-coupled receptor | - |
Mus musculus | ADP + phosphorylated G protein-coupled receptor | - |
? | |
ATP + G protein-coupled receptor | - |
Homo sapiens | ADP + phosphorylated G protein-coupled receptor | - |
? | |
ATP + G protein-coupled receptor | - |
Rattus norvegicus | ADP + phosphorylated G protein-coupled receptor | - |
? | |
ATP + G protein-coupled receptor | regulation mechanism of GRK2, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview | Mus musculus | ADP + phosphorylated G protein-coupled receptor | - |
? | |
ATP + G protein-coupled receptor | regulation mechanism of GRK2, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview | Homo sapiens | ADP + phosphorylated G protein-coupled receptor | - |
? | |
ATP + G protein-coupled receptor | regulation mechanism of GRK2, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview | Rattus norvegicus | ADP + phosphorylated G protein-coupled receptor | - |
? | |
additional information | GRKs are involved in diverse physiological processes and pathologies, overview | Mus musculus | ? | - |
? | |
additional information | GRKs are involved in diverse physiological processes and pathologies, overview | Homo sapiens | ? | - |
? | |
additional information | GRKs are involved in diverse physiological processes and pathologies, overview | Rattus norvegicus | ? | - |
? | |
additional information | GRK2 functionally ineracts with clathrin, phosphoinositol 3-phosphate kinase-gamma, and G protein-coupled receptor kinase interacting protein, GIT | Mus musculus | ? | - |
? | |
additional information | GRK2 functionally ineracts with clathrin, phosphoinositol 3-phosphate kinase-gamma, and G protein-coupled receptor kinase interacting protein, GIT | Homo sapiens | ? | - |
? | |
additional information | GRK2 functionally ineracts with clathrin, phosphoinositol 3-phosphate kinase-gamma, and GIT | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | betaARK subfamily multidomain structure, overview | Mus musculus |
More | betaARK subfamily multidomain structure, overview | Homo sapiens |
More | betaARK subfamily multidomain structure, overview | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
betaARK1 | - |
Mus musculus |
betaARK1 | - |
Homo sapiens |
betaARK1 | - |
Rattus norvegicus |
betaARK2 | - |
Mus musculus |
betaARK2 | - |
Homo sapiens |
betaARK2 | - |
Rattus norvegicus |
G protein-coupled receptor kinase | - |
Mus musculus |
G protein-coupled receptor kinase | - |
Homo sapiens |
G protein-coupled receptor kinase | - |
Rattus norvegicus |
GRK2 | - |
Mus musculus |
GRK2 | - |
Homo sapiens |
GRK2 | - |
Rattus norvegicus |
GRK3 | - |
Mus musculus |
GRK3 | - |
Homo sapiens |
GRK3 | - |
Rattus norvegicus |
More | enzymes belong to the GRK family, GRK2 and GRK3, i.e. betaARK1 and betaARK2, form the betaARK subfamily | Mus musculus |
More | enzymes belong to the GRK family, GRK2 and GRK3, i.e. betaARK1 and betaARK2, form the betaARK subfamily | Homo sapiens |
More | enzymes belong to the GRK family, GRK2 and GRK3, i.e. betaARK1 and betaARK2, form the betaARK subfamily | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |