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Literature summary for 2.7.11.15 extracted from

  • Urasawa, K.; Yoshida, I.; Takagi, C.; Onozuka, H.; Mikami, T.; Kawaguchi, H.; Kitabatake, A.
    Enhanced expression of beta-adrenergic receptor kinase 1 in the hearts of cardiomyopathic Syrian hamsters, BIO53.58 (1996), Biochem. Biophys. Res. Commun., 219, 26-30.
    View publication on PubMed
Search for more literature for 2.7.11.15

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mesocricetus auratus
cDNA encoding beta-ARK 1 is cloned from heart and sequenced, 689 amino acids protein, 95% homology to rat and 90% homology to human beta-ARK 1 Mesocricetus auratus
nucleotide sequence of beta-ARK 1, 95% homology to Syrian hamster beta-ARK 1 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-adrenergic receptor Rattus norvegicus
-
 ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor Mesocricetus auratus beta-ARK 1 might be involved in uncoupling and down-regulation of beta-AR, presumably both beta1- and beta2-AR, in failing hearts via receptor phosphorylation ADP + phospho-beta-adrenergic receptor
-
 ?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
 Syrian hamster, healthy F1b and cardiomyopathic BIO53.58, 7, 15 and 20 weeks old, beta-ARK 1
-
Mesocricetus auratus Q64682
-
-
Rattus norvegicus
-
 beta-ARK 1
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-
heart enhanced expression of beta-adrenergic receptor kinase 1 in the hearts of cardiomyopathic Syrian hamsters, BIO53.58 Mesocricetus auratus
-
heart significantly increased expression of beta-ARK 1 in the hearts of BIO53.58 hamsters compared to control hamsters F1b Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-adrenergic receptor
-
 Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor beta-ARK 1 might be involved in uncoupling and down-regulation of beta-AR, presumably both beta1- and beta2-AR, in failing hearts via receptor phosphorylation Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?

Synonyms

Synonyms Comment Organism
beta-adrenergic receptor kinase 1
-
 Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
ATP
-
 Mesocricetus auratus