Literature summary for 2.7.11.14 extracted from

Kolesnikov, A.V.; Chrispell, J.D.; Osawa, S.; Kefalov, V.J.; Weiss, E.R.
Phosphorylation at serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors (2020), FASEB J., 34, 2677-2690 .

Search for more literature for 2.7.11.14

Protein Variants

Protein Variants	Comment	Organism
S21A	the mutation prevents dark-dependent phosphorylation of isoform GRK1. Rod dark adaptation following exposure to bright bleaching light is significantly delayed in mutant S21A mice, suggesting that the higher activity of this kinase results in enhanced rhodopsin phosphorylation and therefore delays its regeneration. In contrast, dark adaptation of cones is unaffected by the mutation	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + rhodopsin	Mus musculus	-	ADP + phosphorhodopsin	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9WVl4	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	the enzyme is phosphorylated in the dark at Ser21 in a cAMP-dependent manner and dephosphorylated in the light. Dephosphorylation of Ser21 increases enzyme activity, leading to increased phosphorylation of rhodopsin. Phosphorylation at Ser21 is required for normal kinetics of dark adaption in rod but not cone photoreceptors	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
retina	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + rhodopsin	-	Mus musculus	ADP + phosphorhodopsin	-	?

Synonyms

Synonyms	Comment	Organism
G protein-coupled receptor kinase 1	-	Mus musculus
GRK1	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)