Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GRK1 peptides | bovine commercial preparation, inhibition analysis of enzyme binding to S-modulin, overview | Lithobates catesbeianus | |
S-modulin/recoverin | recombinant myristoylated S-modulin overexpressed in Escherichia coli, GRK1 activity is inhibited by binding of the Ca2+-bound form of S-modulin/recoverin, determination of the binding site by peptide mapping, binding involves Leu6, Asn12, and Tyr15, mutation of these residues reduces the inhibition significantly, inhibition mechanism, overview | Lithobates catesbeianus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Lithobates catesbeianus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | GRK1 activity is inhibited by binding of the Ca2+-bound form of S-modulin/recoverin | Lithobates catesbeianus | |
Mg2+ | - |
Lithobates catesbeianus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + rhodopsin | Lithobates catesbeianus | GRK1 is a visual pigment kinase in rods and is essential for inactivation of light-activated rhodopsin | ADP + phosphorhodopsin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Lithobates catesbeianus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retinal rod | - |
Lithobates catesbeianus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + rhodopsin | - |
Lithobates catesbeianus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | GRK1 is a visual pigment kinase in rods and is essential for inactivation of light-activated rhodopsin | Lithobates catesbeianus | ADP + phosphorhodopsin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GRK1 | - |
Lithobates catesbeianus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Lithobates catesbeianus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Lithobates catesbeianus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Lithobates catesbeianus |