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Literature summary for 2.7.11.14 extracted from

  • Zhao, X.; Huang, J.; Khani, S.C.; Palczewski, K.
    Molecular forms of human rhodopsin kinase (GRK1) (1998), J. Biol. Chem., 273, 5124-5131.
    View publication on PubMed
Search for more literature for 2.7.11.14

Application

Application Comment Organism
medicine mutation in RK is associated with the Oguchi disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cloning of one GRK1 from cone-dominant retina Gallus gallus
GRK1 and GRK1b are cloned from fovea, sequenced and expressed in Escherichia coli M15, GRK1b is a splice variant of GRK1 with low catalytic activity transcribed in photoreceptors, GRK1b is produced by retention of the last intron 6 and differs in its C-terminal region next to the catalytic domain Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mg2+
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + rhodopsin Homo sapiens important enzyme of phototransduction ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin Gallus gallus important enzyme of phototransduction ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin Homo sapiens light-dependent initiating of deactivation of rhodopsin ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin Gallus gallus light-dependent initiating of deactivation of rhodopsin ADP + phosphorhodopsin
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus O73685
-
-
Homo sapiens
-
 GRK1 and its splice variant GRK1b
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged GRK1 and GRK1b, expressed in Escherichia coli M15 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
eye retina Homo sapiens
-
eye retina Gallus gallus
-
pineal gland expression of retinal GRK1 Gallus gallus
-
retina in rod and cone photoreceptors Homo sapiens
-
retina in rod and cone photoreceptors Gallus gallus
-
retina photoreceptors also transcribe the splice variant of GRK1 named GRK1b, which is not cone-specific Homo sapiens
-
retina rod-dominant retina, use of cone-enriched fovea, GRK1 occurs mainly in cone outer segments, to a lesser degree in rod outer segments, in all classes of cone cells Homo sapiens
-
retina cone-dominant retina Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + rhodopsin highly specific for photobleached rhodopsin Homo sapiens ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin highly specific for photobleached rhodopsin Gallus gallus ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin important enzyme of phototransduction Homo sapiens ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin important enzyme of phototransduction Gallus gallus ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin light-dependent initiating of deactivation of rhodopsin Homo sapiens ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin light-dependent initiating of deactivation of rhodopsin Gallus gallus ADP + phosphorhodopsin
-
 ?