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Literature summary for 2.7.11.13 extracted from

  • Katoh, T.; Tomata, Y.; Setoh, M.; Sasaki, S.; Takai, T.; Yoshitomi, Y.; Yukawa, T.; Nakagawa, H.; Fukumoto, S.; Tsukamoto, T.; Nakada, Y.
    Practical application of 3-substituted-2,6-difluoropyridines in drug discovery Facile synthesis of novel protein kinase C theta inhibitors (2017), Bioorg. Med. Chem. Lett., 27, 2497-2501 .
    View publication on PubMed
Search for more literature for 2.7.11.13

Inhibitors

Inhibitors Comment Organism Structure
(2R)-2-[(2S)-4-[5-chloro-6-(1H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol
-
 Homo sapiens
1-[3-chloro-6-(1,4-diazepan-1-yl)pyridin-2-yl]-7-ethoxy-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one
-
 Homo sapiens
15-chloro-11-methyl-8,9,10,11-tetrahydro-7H-16,12-(azeno)-6-oxa-2,3,11,16a-tetraazacyclotetradeca[1,2,3-cd]inden-1(2H)-one
-
 Homo sapiens
2-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-6-(2-phenylpiperazin-1-yl)pyridine-3-carbonitrile
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q04759
-
-

Synonyms

Synonyms Comment Organism
PKCtheta
-
 Homo sapiens
protein kinase C theta
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000000086
-
 pH and temperature not specified in the publication Homo sapiens 1-[3-chloro-6-(1,4-diazepan-1-yl)pyridin-2-yl]-7-ethoxy-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one
0.00000087
-
 pH and temperature not specified in the publication Homo sapiens 15-chloro-11-methyl-8,9,10,11-tetrahydro-7H-16,12-(azeno)-6-oxa-2,3,11,16a-tetraazacyclotetradeca[1,2,3-cd]inden-1(2H)-one
0.0000063
-
 pH and temperature not specified in the publication Homo sapiens 2-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-6-(2-phenylpiperazin-1-yl)pyridine-3-carbonitrile