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Literature summary for 2.7.11.13 extracted from

  • Lopez-Sanchez, I.; Garcia-Marcos, M.; Mittal, Y.; Aznar, N.; Farquhar, M.G.; Ghosh, P.
    Protein kinase C-theta (PKCtheta) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin (2013), Proc. Natl. Acad. Sci. USA, 110, 5510-5515.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Galpha-interacting, vesicle-associated protein PKCtheta, down-regulates Galpha-interacting, vesicle-associated protein (GIV's) guanine exchange factor, GEF function by phosphorylating Ser-1689 located within GIV's GEF motif. PKCtheta specifically binds and phosphorylates GIV at S1689, and this phosphoevent abolishes GIV's ability to bind and activate trimeric G proteins Galphai Homo sapiens ADP + phosphorylated-Galpha-interacting, vesicle-associated protein
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Synonyms

Synonyms Comment Organism
PKCtheta
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
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assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

General Information

General Information Comment Organism
physiological function phosphorylation of Galpha-interacting, vesicle-associated protein (GIV) by PKCtheta inhibits GIV's guanine exchange factor (GEF) function and generates a unique negative feedback loop for downregulating the GIV-Gi axis of prometastatic signaling downstream of multiple ligand-activated receptors Homo sapiens