Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Galpha-interacting, vesicle-associated protein | PKCtheta, down-regulates Galpha-interacting, vesicle-associated protein (GIV's) guanine exchange factor, GEF function by phosphorylating Ser-1689 located within GIV's GEF motif. PKCtheta specifically binds and phosphorylates GIV at S1689, and this phosphoevent abolishes GIV's ability to bind and activate trimeric G proteins Galphai | Homo sapiens | ADP + phosphorylated-Galpha-interacting, vesicle-associated protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKCtheta | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | phosphorylation of Galpha-interacting, vesicle-associated protein (GIV) by PKCtheta inhibits GIV's guanine exchange factor (GEF) function and generates a unique negative feedback loop for downregulating the GIV-Gi axis of prometastatic signaling downstream of multiple ligand-activated receptors | Homo sapiens |