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Literature summary for 2.7.11.13 extracted from

  • Martin, P.; Pognonec, P.
    ERK and cell death: cadmium toxicity, sustained ERK activation and cell death (2010), FEBS J., 277, 39-46.
    View publication on PubMed
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
4beta-phorbol 12-myristate 13-acetate
-
 Homo sapiens
additional information PKC activation can inhibit zinc transporter ZIP8 activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GF 109203X broad-spectrum PKC inhibitor Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ cell exposure to 0.020 mM cadmium for 24 h results in PKC activation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + extracellular signal-related kinase
-
 Homo sapiens ADP + phosphorylated extracellular signal-related kinase
-
 ?

Synonyms

Synonyms Comment Organism
PKC
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens prolonged PKC activation by phorbol esters is downregulates PKC for at least 24 h down

General Information

General Information Comment Organism
physiological function PKC plays a protective role in cells exposed to cadmium, as its early activation by 4beta-phorbol 12-myristate 13-acetate reduces both delayed extracellular signal-related kinase activation and cadmium toxicity, whereas blocking its activity has the opposite effect Homo sapiens